#Car

A single protein may be holding back CAR T cancer therapy

Researchers from Columbia University and University Hospital Tübingen have discovered a protein that appears to play a major role in weakening CAR T cells over time. The findings, published in Cancer Discovery , could help improve CAR T-cell therapy, particularly against solid tumors that have proven difficult to treat. "Our goal is to improve the effectiveness of CAR T cells in solid tumors as well," says Celina May, co-first author of the study and a member of Prof.